Search results for alzheimer's

“The decline of deep, slow-wave sleep begins early in life, and by the time a person is in their 80s, their deep sleep brain waves are almost undetectable. The fact that poor sleep is linked with the aggregation of amyloid-beta plaques in the brain and Alzheimer's disease is not surprising.”

“Diet and lifestyle play considerable roles in the risk of developing Alzheimer's disease, particularly in people who carry an APOE4 gene variant. Consuming alcohol may be more detrimental to those with an APOE4 allele as they are less able to repair the damage inflicted on the brain.”

“Resveratrol, a plant-based compound found in red grapes and peanuts, exerts beneficial effects on the human brain. Clinical trials have demonstrated that resveratrol reduces levels of amyloid-beta in cerebrospinal fluid and improves cognitive function in people with Alzheimer's disease.”

“During sleep, the brain activates the glymphatic system, a self-cleaning process that rids the brain of metabolic byproducts. One of these byproducts is amyloid-beta, a toxic protein that aggregates and forms plaques in the brain with age and is associated with Alzheimer's disease.”

“Clinical trials have unearthed evidence that is suggestive of the possibility that amyloid-beta build-up in the brain may be being attenuated, as well as an improvement in cognitive function in people with Alzheimer’s disease.”

“Alzheimer's patients have reduced GLUT1, the glucose transporter, at the blood-brain barrier, which may diminish neuronal activity. However, it is unclear which comes first, the breakdown of the blood-brain barrier or the reduced glucose transport, but it is likely a vicious cycle.”

“Vascular dysfunction is a common feature of most forms of dementia, including Alzheimer's disease. Identifying and treating vascular problems in the brain's smallest blood vessels could postpone the onset of symptoms and improve the quality of life for people with dementia.”

“Genetic predisposition, altered glucose uptake in the brain, high blood pressure, and other factors can weaken the barrier's integrity, allowing endotoxins and inflammatory immune cells to infiltrate the brain and increasing a person's risk for dementia.”

“A growing body of evidence suggests that sulforaphane's protective effects extend to the brain, where it appears to enhance brain-derived neurotrophic factor (a protein that controls and promotes the growth of new neurons) and inhibits histone deacetylation (an epigenetic modification that influences gene expression).”

“The trial provides evidence for cognitive and biomarker effects in this population, while the broader question of preventing Alzheimer's disease requires longer-term clinical outcomes. This clip is excerpted, with permission, from Dr. Rhonda Patrick’s presentation at Natural Products Expo West.”