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“BFR training protocols include a frequency of 2-3 times per week, occlusion pressure of 40-80% depending on the limb, using 2 exercises per muscle group, repetition schemes, wear times of 10-20 minutes, loads of 20-50% of 1 rep max, and a tempo of 1-2 seconds for both concentric and eccentric.”

“On the other hand, for people interested in fat loss, breath acetone is a non-invasive tool for estimating fat loss. Dr. D'Agostino describes how he uses the Glucose Ketone Index – a single value biomarker representing the glucose-to-ketone ratio in the blood.”

“The comparison depends on what a dietary fat replaces. Randomized trials show that replacing palmitic acid, a common saturated fat, with unsaturated fats lowers LDL cholesterol and apolipoprotein B without a consistent effect on glucose, insulin, or C-reactive protein.”

“Dr. Patrick adds that plant foods also provide vitamins, minerals, and phytochemicals within a food matrix. Long-term evidence consistently relates higher-quality carbohydrate and fiber intake to better health outcomes.”

“For people who begin in their seventies, Dr. Levine says exercise can still lower blood pressure, improve endothelial function, alter autonomic control, and raise VO2 max even when structural remodeling of the heart is limited.”

“Dr. D'Agostino notes that elevating blood ketones benefits some but not all patients with Alzheimer's disease, suggesting that patient characteristics such as genotype or disease subtype may influence success.”

“The current recommended dietary allowance, or RDA for protein intake is 0.8 grams per kilogram of bodyweight (about 0.36 grams per pound) per day, or about 68 grams for a 150-pound adult. Dr. Phillips asserts that this amount of protein is probably not enough to maintain muscle mass.”

“APOE4 is the strongest common genetic risk factor for late-onset Alzheimer's disease, while physical activity, sleep, blood pressure, and diet remain important modifiable influences across the lifespan. Nutrition may offer additional support.”

“In a randomized trial of resistance-trained women, an eight-hour eating window did not reduce gains in lean mass, muscle thickness, strength, or performance when energy and protein intake were matched and the participants completed supervised resistance training.”

“In this Aliquot, cardiologist Ben Levine, nutritional scientist and champion powerlifter Layne Norton, and I discuss the importance of recovery, how best to approach it, and some surprising, often overlooked aspects of this important part of fitness.”