Search results for insulin

“Studies in animals and humans suggest that brown fat can improve glucose and insulin sensitivity, increase fat oxidation, and protect against diet-induced obesity. Cold exposure increases brown fat volume and metabolism and drives glucose uptake.”

“Participants following the green Mediterranean diet showed the greatest preservation of brain volume, particularly in the hippocampus. They also experienced improvements in HbA1c (a marker of long-term blood glucose control), insulin resistance, fasting glucose, and C-reactive protein.”

“00:08:06 - How the suppression of the IGF-1 pathway, typically a hallmark of prolonged fasting and caloric restriction studies and potentially needed for some of the benefits, may fail to be achieved in human caloric restricters that eat too much protein. 00:09:34 - How certain macronutrients influence the insulin/IGF-1/growth hormone axis interact to modulate aging in many cell types.”

“FGF21 plays a role in many of the beneficial responses to exercise like improved glucose uptake and insulin sensitivity, lower blood cholesterol levels, and reductions in body weight. It also alters dopamine signaling.”

“The mechanisms that drive these effects are thought to be related to improvements in muscle tissues' oxidative capacity, enhanced insulin response, and improvements in heart function (specifically, left ventricle ejection fraction) and vascular compliance (an indicator of blood vessel elasticity and storage capacity).”

“Muscle is a "glucose sink," and engaging more skeletal muscle means more glucose uptake and less glucose in the bloodstream. Exercise enhances glucose uptake independent of insulin, also by increasing GLUT4 translocation to the cell surface in muscles.”

“This systemic inflammation can promote insulin resistance in muscles and fat accumulation in the liver. The downstream effect is accelerated epigenetic aging, a phenomenon that occurs when an individual's epigenetic age exceeds their chronological age.”

“Preliminary studies suggest creatine supplementation can modestly improve endothelial function, which is critical for vascular tone, blood pressure regulation, and cardiovascular health. Creatine supplementation can enhance glucose disposal and improve insulin sensitivity by increasing the expression of GLUT-4 glucose transporters in muscle cells.”

“The long-term outcomes of these complications are often manifested in adulthood as an increased risk of ischemic heart disease, hypertension, and perturbed metabolism, as evidenced by insulin resistance, glucose intolerance, and abnormal lipid profiles.”

“Neurogenesis Whereas the early view of the mammalian central nervous system presumed that it was a static complex incapable of change, a growing body of evidence suggests that it retains its capacity for synaptic pruning – the process that eliminates extra neurons and synaptic connections and establishes new neural circuits to increase the efficiency of neuronal transmissions – throughout life.”