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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“A few examples of genes with common polymorphism discussed are MTHFR and folate, NBPF3 and vitamin B6, FUT2 and vitamin B12, BCMO1 and beta-carotene, FADS2 and omega-3 fatty acids, CYP2R1 and vitamin D, PEMT and choline as well as APOE4 and FOXO3.”

“A key component in these processes is the lactate shuttle – a metabolic pathway that facilitates the movement of lactate between tissues so it can be used as an energy source, effectively recycling it and supporting sustained exercise performance.”

“Dr. Rhonda Patrick visits the Kevin Rose Show to discuss metformin, magnesium L-threonate, fish oil and brain health, sulforaphane, goitrogenic activity of isothiocyanates, sauna, and more. Subscribe to the Kevin Rose Show on iTunes. Learn more about Kevin Rose @kevinrose on Twitter. KevinRose.com. The Kevin Rose Show on iTunes. Foundation by True Ventures.”

“Dr. Patrick starts with the Finnish observational evidence: frequent sauna use and sessions longer than 19 minutes were associated with lower cardiovascular mortality in middle-aged men. That evidence informs her routine, but it does not make her temperature, duration, or frequency a universal prescription.”

“National survey analyses estimated that roughly 38% to 47% of Americans consumed less vitamin C than the Estimated Average Requirement across 1999–2018, while an earlier biomarker survey found clinical vitamin C deficiency in about 7%.”

Tim Ferriss discusses ketosis, the gut microbiome, and monitoring biomarkers to promote performance.

“The effects of heat exposure are broad and include improved immunity, better cardiovascular health, improved mood, and extended healthspan, the number of years we live in good health. Rhonda shares her personal sauna bathing routine and briefly describes special considerations for children and other special groups.”

“Dr. Bruce Ames' Triage Theory Dr. Ames proposed that the body does a strategic rationing so that those proteins and enzymes in the body which are essential for short-term survival get their share of vitamins and minerals at the expense of other proteins and enzymes that are essential for long-term survival.”

“Advanced glycation end-products, or AGEs for short, are created when the sugars, amino acids, and fats in food encounter heat. AGEs also form in the body during normal glucose metabolism. However, if high levels of AGEs accumulate in the tissues and blood, they can become pathogenic.”