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Dr. Rhonda Patrick, Dr. Darya Rose, and Kevin Rose discuss turmeric's ability to increase detoxification enzymes through hormesis.

“A systematic review and meta-analysis of 44 randomized trials found that berberine improved several surrogate measures, including inflammatory biomarkers, stroke-related neurological deficit scores, and carotid intima-media thickness.”

“When Dr. Bill Harris began researching omega-3 in the early 1980s, he was looking for an impact on cholesterol with what would be considered a high dose by today's standards: around 25 effective grams per day of omega-3 from salmon.”

“While both can be useful (depending on context), they have different implications: much like a person's glucose may fluctuate throughout the day, standard lab measures of omega-3 rely on plasma, biasing them to the content of a recent meal.”

“Exercise can improve blood pressure, insulin sensitivity, triglycerides, and fitness, but someone with high ApoB or LDL may still need targeted diet changes and clinician-guided lipid-lowering treatment. Mood is another major benefit.”

“And, although these products are widely available on the common market in supplement form, Dr. Sinclair does not endorse them, preferring to focus his efforts on developing pharmaceutical-grade products. In this clip, Dr. David Sinclair discusses the economic issues associated with research using nicotinamide riboside and nicotinamide mononucleotide.”

“Limiting evening light exposure, decreasing the temperature of the room in which we sleep, reducing our anxiety, and restricting the intake of substances that alter our alertness can have demonstrable effects on improving our sleep.”

“In another randomized trial, advice to drink an additional 1.5 liters of water daily improved migraine-specific quality of life, even though headache-day counts did not clearly change. Selected nutrients may help some people as part of a broader prevention plan.”

“Elevated levels of ketone bodies, such as beta-hydroxybutyrate, can have beneficial effects on several brain-related diseases. Research suggests that ketone bodies can increase blood flow in the brain by 30 to 40 percent, which may have profound effects for patients with brain injury or vascular dementia.”

“Studies in animals show that if Mfsd2a is defective or missing (which can happen with age or genetics), DHA levels in the brain decrease by more than 50%, potentially compromising the blood-brain barrier.”