Search results for epigenetics

Dr. Rhonda Patrick and Dr. Steve Horvath discuss COSMOS multivitamin findings for cognition and epigenetic aging in older adults.

“This concept forms the basis of the Informational Theory of Aging, an idea put forth by Dr. Sinclair and elaborated upon in his book Lifespan, in which he analogizes aspects of the epigenetic signature of aging and its ability to be reset to the signal correction capabilities of TCP/IP protocol.”

Dr. Rhonda Patrick reviews a post hoc analysis of a three-year omega-3 trial that found small changes in selected epigenetic aging clocks in older adults.

“Judith Carroll - UCLA researcher cited for her work on sleep disturbances, the Women's Health Initiative, and epigenetic age. Laura Kubzansky - Harvard social and behavioral scientist. Arthur Brooks - Harvard happiness researcher and FMF guest.”

“Scientific evidence suggests that epigenetic changes can be passed from generation to generation. Three biochemical processes drive epigenetic change: DNA methylation, histone modification, and non-coding RNA-associated gene silencing.”

“The investigators suggested this decrease in monocytes and subsequent increase in NAD+ may be responsible for the reversal of epigenetic aging. The main purpose of this pilot trial was to determine the safety and efficacy of the intervention.”

“Epigenetic alterations, non-sequential changes in DNA that accumulate over time and contribute to the loss of proteostasis. Loss of proteostasis, the inability of cells to maintain the levels of proteins and enzymes needed for a cell to function correctly.”

“These proteins, now called Yamanaka factors, are highly expressed in embryonic stem cells in mice and humans. Their short-term expression can ameliorate cellular and physiological hallmarks of aging and prolong lifespan by resetting the Horvath epigenetic clock.”

“However, the DNAm GrimAge epigenetic clock is a highly reliable predictor of healthspan and lifespan, based on DNAm surrogates in blood, including biomarkers of aging and alterations in blood composition. In this clip, Dr. Steve Horvath discusses the strengths and weaknesses of using telomeres versus epigenetic clocks to predict risk of disease and death.”

“Liquid biopsy correctly identified 70 percent of cancer patients and 87 percent of healthy controls. The accuracy improved when the reviewers included only studies with modern assessments of genetic and epigenetic irregularities in cfDNA.”