Discovery of genes that reset the Horvath Clock | David Sinclair

Parent Episode: Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

Dr. Shinya Yamanaka discovered a group of proteins that can reprogram differentiated (mature) cells into pluripotent stem cells. These proteins, now called Yamanaka factors, are highly expressed in embryonic stem cells in mice and humans. Their short-term expression can ameliorate cellular and physiological hallmarks of aging and prolong lifespan by resetting the Horvath epigenetic clock. In this clip, Dr. David Sinclair talks about the discovery of genes that can reset the Horvath epigenetic clock.

Member support keeps us strong.

If you enjoy the fruits of foundmyfitness, you can participate in helping us to keep improving it. Creating a pay-what-you-can subscription does just that! Plus, we throw in occasional member perks and, more importantly, churn out the best possible content without concerning ourselves with the wishes of any dark overlords.

Our website is 100% supported by people like you through this pay-what-you-can mechanism.

Monthly Support

  • Fundamentals

    $15 / month
  • Loyal Fan

    $25 / month
  • Super Fan

    $50 / month
  • Power Supporter

    $125 / month
  • Heroic Supporter

    $250 / month

One-time Support

You can also become a one-time supporter with a single donation in any amount.