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Dr. Rhonda Patrick discusses xylitol safety, strategies to reduce hemoglobin A1C, klotho and dementia risk, and the timing of hormone replacement therapy.

“In STEP 1, once-weekly semaglutide plus lifestyle support produced an average weight reduction of 14.9% over 68 weeks, compared with 2.4% with placebo, establishing strong efficacy for selected adults with overweight or obesity.”

“Alternative practices have the promise to create a transformational path that may be protective against depression. In this clip, Dr. Charles Raison discusses his belief that ancient practices are more likely than modern pharmacology to encourage resilience and stave off depression.”

“In another randomized trial, advice to drink an additional 1.5 liters of water daily improved migraine-specific quality of life, even though headache-day counts did not clearly change. Selected nutrients may help some people as part of a broader prevention plan.”

“Dr. Montagne's animal research demonstrated that blocking cyclophilin A partially restored vascular function and cognition, suggesting that targeting the blood-brain barrier could be a promising avenue for Alzheimer's treatment.”

“Meditation is a form of mental training geared toward improving aspects of a person's core neurocognitive function, such as the regulation of attention and emotion. Research suggests that meditation may protect the brain from the negative effects of stress and promote mental health.”

“Dr. Roland Griffiths is a clinical pharmacologist at Johns Hopkins and one of the world's foremost researchers on the psychedelic compound psilocybin. Learn more about Dr. Roland R. Griffiths Johns Hopkins Profile - Roland R. Griffiths. List of Publications.”

Dr. Rhonda Patrick discusses Akkermansia muciniphila, vitamin B1's effect on blood sugar, emulsifiers in food, and electrolyte supplements.

“Dr. Huberman connects that result with open questions about memory consolidation, trauma therapy, and recovery from sleep loss, while keeping those applications as research directions rather than established replacements for sleep.”

“Timing matters when cold exposure follows resistance training. In a 12-week study of 21 men, ten minutes of cold-water immersion immediately after each session attenuated gains in strength and muscle mass and reduced selected anabolic signals.”