Search results for autophagy

“↓ tumor suppressor gene activity → ↓ autophagy → survival of pre-malignant cells → ↑ autophagy as a malignant adaptation. 00:44:49 - How inhibition of autophagy _by itself is sufficient to induce oncogenesis, particularly in leukemia.”

“Similarly, in a transgenic mouse model of Huntington's disease, oral berberine (40 mg/kg/bw) per day increased autophagy, which, in turn, promoted cellular degradation of mutant huntingtin, the protein implicated in the pathogenesis of the disease.”

“Specific topics include autophagy, the process of recycling dysfunctional cells that is induced by fasting and fasting-mimicking drugs such as resveratrol and spermidine. Rhonda discusses the effects of fasting on Parkinson's disease and which groups of people should not fast.”

“Endothelial dysfunction increases with age and contributes to inflammaging, a process of tissue degeneration characterized by altered cellular senescence, immunosenescence, mitochondrial dysfunction, defective autophagy, metabolic inflammation, and gut microbiota dysbiosis.”

“Coordination of meal timing with the circadian rhythm can reduce markers of inflammation and affect aspects of metabolic health, including glucose regulation and insulin sensitivity. Animal studies suggest that overnight fasting induces autophagy.”

“A commonly observed behavior among mammals is the so-called "sickness behavior," where a person or animal that is sick will retreat, avoiding food and contact. This abstention from food induces autophagy and may serve as a means to modulate the body's inflammatory response.”

“Dr. Valter Longo on Resetting Autoimmunity and Rejuvenating Systems with Prolonged Fasting & the FMD. Ruth Patterson, Ph.D. on Time-Restricted Eating in Humans & Breast Cancer Prevention. Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation.”

“One of the mechanisms associated with resveratrol's actions is the activation of autophagy, a cellular defense program that targets old, damaged proteins for destruction and recycling. In this clip, Dr. David Sinclair and Dr. Rhonda Patrick discuss the brain health benefits associated with resveratrol.”

“Dr. Patrick raises autophagy as one proposed fasting mechanism, while Dr. Norton stresses that autophagy also occurs with energy restriction and exercise and is not unique to time-restricted eating. More autophagy is not uniformly beneficial in every tissue or disease context.”

“Interestingly, mice that are fed on an intermittent fasting schedule adjust to their restricted regimen and, in the end, tend to weigh as much as mice fed on a normal schedule, but they exhibit many of the physiological responses – including induction of autophagy – as calorie-restricted mice.”