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“Metformin, a drug commonly used to treat type 2 diabetes, has garnered interest as a longevity compound because it was shown to extend lifespan in some animal models. These effects are variable and seem to depend on the age and gender of the animals, as well as the dose provided.”

“Aside from just being able to better tolerate the cold, Wim has also demonstrated another interesting property of his method: in a 2012 study he showed he was able to suppress his response to bacterial endotoxin.”

“Dr. Huberman therefore uses a subjective ‘wall’ model rather than a rigid prescription: enter safely, notice the first strong urge to leave, and practice staying calm long enough to complete the planned exposure.”

“The abundance of glucoraphanin in broccoli seeds suggests that consuming the seeds (rather than sprouting them) provides a better means of obtaining the end product – sulforaphane.”

“Ghrelin, a hormone produced in the gut that signals hunger, acts on cells in the hypothalamus to stimulate appetite, increase food intake, and promote growth. It is often referred to as the "hunger hormone."”

“Multiple age-related inputs can keep innate immune pathways active, including the senescence-associated secretory phenotype, mitochondrial damage and oxidative stress, debris released by injured cells, visceral adipose tissue inflammation, chronic infections, increased intestinal permeability, and dysbiosis.”

“This video was produced mostly in response to some over-the-top spin the media placed on an otherwise interesting paper entitled: Variation in cancer risk among tissues can be explained by the number of stem cell divisions.”

“A systematic review and meta-analysis of 44 randomized trials found that berberine improved several surrogate measures, including inflammatory biomarkers, stroke-related neurological deficit scores, and carotid intima-media thickness.”

“The Omega-3 Index is a marker for cardiovascular risk "But interesting to me is that all these other causes of death – from electrocution to suicide, to car accidents, to kidney failure, you know, everything people died of – the higher the omega-3, the lower the risk."”

“Translating animal studies to humans While the hypotheses proposed by animal studies are interesting and suggest a mechanistic element to the observational studies connecting red meat and health risks, concluding how these findings translate to humans is challenging.”