Search results for senescence

“FTA: > Intermittent dosing with rapamycin breaks the inflammatory loop associated with senescence, scientists report. Once disrupted, it takes time for the loop to reestablish itself -- providing proof-of-principal that intermittent dosing could provide a way to reap the benefits of rapamycin while bypassing its safety issues. The FDA-approved drug increases healthspan and lifespan in mice.”

“FTA: > Mild infections without symptoms of illness can still lead to serious consequences by reducing the lifespan of the infected individuals, research shows. A new study has been carried out on malaria-infected migratory birds. The infection is thought to speed up the aging process by shortening the telomeres (i.e., the chromosomes ends) at a faster rate and thereby accelerating senescence.”

“Participants reported their activity by recording which, if any, of 62 physical activities they participated in during the past 30 days and how often. Telomere length and cell senescence are closely related to inflammation and oxidative stress.”

“When the telomeres on a cell's chromosomes get too short, the chromosome reaches a "critical length," and the cell enters senescence or undergoes apoptosis. Telomere length is measured in base pairs – the coupled building block units that make up the ladder-like rungs of our DNA.”

“It was able to repair damaged skin cells, lower the rate of cell death, increase the rate of cell division, reduce reactive oxygen species, and reduce markers of cellular senescence in skin from both middle-aged donors and elderly.”

“Manuel Serrano - aging, senescence, and reprogramming researcher. David Sinclair - Harvard aging researcher and FMF guest with notable work in partial reprogramming and an optic-nerve regeneration clinical trial. *See my episode featuring Dr. David Sinclair.”

“To test psilocybin's potential effects on aging, researchers treated human lung and skin cells with psilocin in the lab. They tracked how long the cells kept dividing before entering senescence—a state where cells stop dividing and begin to deteriorate.”

“They repeated their experiment in monkeys, worms, and yeast and observed similar effects. They also found that taurine reduced several hallmarks of aging in all the species studied, including cellular senescence, mitochondrial dysfunction, DNA damage, and inflammation.”

“In addition, the cellular senescence that accompanies aging activates pro-inflammatory signaling pathways and drives the release of cytokines, chemokines, and growth factors. Other contributors to inflammaging are cellular debris from normal cell death and the accumulation of metabolic byproducts, such as amyloid-beta proteins, which are involved in the pathogenesis of Alzheimer's disease.”