The negative effects of obesity mimic the aging process.
“Telomeres are distinctive structures comprised of short, repetitive sequences of DNA located on the ends of chromosomes. They form a protective “cap” – a sort of disposable buffer that gradually shortens with age.”
Episode
Joe Rogan Experience #1054 - Dr. Rhonda Patrick
“01:28:50 - Healthy adults who drink 12 ounces of sugar-sweetened soda beverages per day may have accelerated aging as evidenced by shorter telomeres. Study. 01:28:50 - Consuming 75 grams of sugar a day decreases testosterone 25% in men.”
Metformin inhibits mitochondrial adaptations and improvements in cardiorespiratory fitness after aerobic exercise training in older adults.
“Metformin inhibits mitochondrial adaptations and improvements in cardiorespiratory fitness after aerobic exercise training in older adults. Metformin also diminished whole-body insulin sensitivity after aerobic exercise. Metformin did not diminish the improvements in HbA1c, fasting insulin, 24‐hr mean glucose, and fat mass or the increase in skeletal muscle telomere length after exercise.”
Psilocybin, a compound in psychedelic mushrooms, extends cellular lifespan by up to 57% and promotes healthy aging in mice, implying potential anti-aging benefits.
“Cells treated with a low dose of psilocin lived 29% longer than untreated cells, while a higher dose extended lifespan by 57%. These cells showed fewer signs of aging, such as oxidative damage and markers of cellular stress, and maintained longer telomeres.”
Removing senescent cardiac muscle cells from the hearts of aged mice, both genetically and using drugs, reduces hypertrophy and fibrosis in aged heart
“DNA damage at telomeres drives senescence in cardiac cells. Removing senescent cardiac muscle cells from the hearts of aged mice, both genetically and using drugs, reduces hypertrophy and fibrosis in aged hearts and restores cardiac health.”
Lifespan of mice extended by 25% by making a genome edit that promoted the death of cells right as they turn senescent.
“This also had the effect of reducing the formation of cataracts, heart and kidney deterioration, and tumor formation! Senescent cells are cells that have essentially run out of telomeres, and are no longer behaving how they're supposed to.”
New iTunes podcast on stress & meditation! Eight weeks of meditation increased brain volume in 4 different regions.
“In this podcast I talk about how stress accelerates brain aging, causes gut permeability, depresses the immune system, and accelerates telomere attrition. Additionally, I discuss how meditation has been shown to buffer against these negative effects on the brain and body by decreasing rumination, increasing gamma wave production, neuroplasticity, brain volume, and telomerase activity.”
Yoga increases the volume of a brain region involved in learning and memory and changes several brain regions involved in emotional regulation.
“Link to full study. Watch this clip about the antidepressant qualities of hot yoga, featuring Dr. Charles Raison. Watch this clip about biohacks (including yoga) that increase telomere length, featuring Dr. Elissa Epel.”
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