Search results for hypoxia

“Lesions located in the basal ganglia result in movement disorders such as Parkinson's disease. Small vessel disease leads to hypoperfusion and hypoxia in the brain, causing protein misfolding and downstream endothelial dysfunction, BBB break-down, and inflammation.”

“Hyperbaric (i.e., high air pressure) treatments use increased atmospheric pressure and oxygen content to enhance the total amount of oxygen dissolved in the body, accelerating wound healing. Some forms of routine hyperbaric therapy cause the body to react as if it were experiencing hypoxia (i.e., low blood oxygen), a phenomenon called the hyperoxic-hypoxic paradox.”

“The process of autophagy is activated by cellular stressors such as nutrient depletion, hypoxia, and toxins and involves myriad genes, proteins, receptors, and signaling pathways. Although autophagy occurs at the cellular level, its activation at the whole-body level may improve metabolic fitness and extend lifespan.”

“(See "Mitochondrial dysfunction" above) Learn more about sauna use and heat shock proteins in our overview article. Cold exposure via cold-water immersion or cryotherapy induces cold shock proteins, a large family of proteins that respond to cellular stressors such as cold exposure, DNA damage, and hypoxia.”

“The study's authors transplanted irradiated porcine kidney cells into the aortas of mice. After four weeks, the authors observed renal hypoxia and elevated plasma creatinine, indicative of renal injury in the treated mice.”

“Cold shock proteins, a large family of highly conserved proteins induced by various cellular stressors such as cold exposure, DNA damage, and hypoxia, lessen the harmful effects of cold.”

“During exposure to stress from temperature extremes, reduced nutrient levels (as in fasting), or hypoxia (reduced oxygen), cells increase expression of HSPs to stabilize unfolded proteins and repair or re-synthesize damaged ones.”

“Early intervention in the treatment of traumatic brain injury is vital to mitigate damage to brain tissue. Administering lactate or ketones following a brain injury might lessen the damage caused by hypoxia and spare glucose for essential processes, like the recycling of the antioxidant glutathione.”

“Lactate, which is produced during exercise, acts similarly to ketones, and under conditions of hypoxia (which can occur during exercise), it can be used as an alternate fuel source. In particular, lactate crosses the blood-brain barrier for use by neurons as an energy source.”