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“In addition, a randomized, placebo-controlled, double-blind trial involving people diagnosed with mild-to-moderate dementia due to Alzheimer's disease found that participants who took a resveratrol supplement twice a day (up to 1 gram) for one year exhibited reduced levels of MMP9, a neurological inflammatory marker associated with increased neurodegeneration and inflammation.”
Small vessel disease is a generic term that describes dysfunction of blood vessels that occurs with aging and contributes to cognitive decline, cardiovascular disease, frailty, and stroke.
“After taking into account other factors, including age, race/ethnicity, poverty/income, tobacco and alcohol consumption, and physical activity, the authors also found that participants with overweight and obesity were nearly four times more likely to have low serum testosterone compared to lean males, independent of SSB consumption.”
“Robust evidence from epidemiological, clinical, rodent, and in vitro studies has demonstrated that sulforaphane exhibits antioxidant and anti-inflammatory properties and may be beneficial against a wide range of chronic and acute diseases, including autism, cancer, metabolic dysfunction, and many others and may ameliorate some of the harmful effects associated with exposure to air pollution.”
Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells that play an important role in intestinal permeability and inflammaging.
“UPFs cause metabolic and cognitive changes in less than a week "...just 5 days of a high-calorie diet made the brains of these healthy, normal weight men structurally and functionally similar to people with obesity, and even after cutting the high-calorie foods out of their diet, these changes persisted for at least one week."”
“In a trial of middle-aged, low-fitness adults, urolithin A supplementation led to a 10–12% increase in lower-body muscle strength, a 10–15% increase in VO2 peak, and better performance on a 6-minute walk test, even when participants didn't engage in structured exercise training over the 4-month study.”
Intravenous Vitamin C for the treatment of sepsis Sepsis, a life-threatening condition that can arise due to the body's response to a bacterial or viral infection, can cause severe injury to multiple tissues or organs.(Source: CDC) (https://www.cdc.gov/sepsis/index.html) People diagnosed with sepsis typically have low vitamin C levels, which might be predictive of increased risk for organ failure.
“For example, exposure to ultraviolet B light is the primary source of vitamin D, but behaviors or characteristics that block or reduce sun exposure, such as using sunscreen, having high levels of melanin (a dark pigment found in skin that acts like natural sunscreen), exclusive breastfeeding, older age, or being obese can impair the skin's ability to produce vitamin D3.”
Zinc is an essential nutrient that influences growth and development and plays critical roles in immune function, protein synthesis, wound healing, DNA synthesis, and cell division.