FoundMyFitness library
Ranked by shared topics.
“While aerobic exercise is often viewed preferentially through the lens of cardiovascular health, the diverse cascade of biological effects from exercise as a whole — and aerobic exercise, in particular — culminate to make it one of the most formidable and immediately practical real-world interventions for human aging and the brain.”
“Caloric restriction, a potent inducer of autophagy, extends lifespan in many organisms but also reduces the risk of many age-related chronic diseases, such as diabetes, cardiovascular disease, cancer, and brain atrophy – likely attributable to the beneficial effects of autophagy.”
“Assessments of episodic memory based on a battery of cognitive tests demonstrated that the rate of cognitive decline experienced by healthy, older people who had amyloid-beta protein accumulation in their brain and who were APOE4 and BDNF Met carriers was roughly three times the rate of decline among those carrying only the BDNF Val allele (the more common form of the gene that retains valine).”
“A mouse study demonstrated that oral berberine (50 or 100 mg/kg/bw per day) reversed the depression-inducing effects of corticosterone injection by upregulating hippocampal synthesis of brain-derived neurotrophic factor – a type of protein that acts on neurons in the central and peripheral nervous systems and may be important for the antidepressant response.”
“However, two small, randomized, double-blind, placebo-controlled experiments in which participants received BHB supplements (as ketone salt or ketone monoester) found that various markers of NLRP3 inflammasome activation, including caspase-1 and interleukin 1-beta, increased, suggesting that the ketones may have unintended proinflammatory effects.”
“Microbial production of short-chain fatty acids, including acetate and propionate, occurs in the colon during the fermentation of indigestible fibers found in plant foods such as legumes, fruits, nuts, cereals, and whole grains.”
“In a randomized crossover study, eight trained men completed four days of daily cycling while eating either a low-carbohydrate, high-fat diet (12 percent carbohydrate) or a normal-carbohydrate diet (62 percent carbohydrate).”
“Neurogenesis Whereas the early view of the mammalian central nervous system presumed that it was a static complex incapable of change, a growing body of evidence suggests that it retains its capacity for synaptic pruning – the process that eliminates extra neurons and synaptic connections and establishes new neural circuits to increase the efficiency of neuronal transmissions – throughout life.”
“Furthermore, while a higher dose of exercise (i.e., 300 minutes per week) was best for improving waist circumference, that same wasn't true for body fat percentage, which was reduced the most (2.1%) at 150 minutes per week, and body fat mass, which was reduced the most (2 kg or 4.4 lb) at 100 minutes per week of exercise.”
“Exercise–In All Forms—Reduces Depression and Anxiety For the latest study on exercise for depression and anxiety, researchers meta-analyzed a total of 26 randomized controlled trials that compared either aerobic exercise, resistance exercise, or combined training to a control intervention—usually a standard of care such as medication, CBT, counseling, or health education.”