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Ranked by shared topics, with one result from each original episode.

81
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Aliquot #82: Reducing Alzheimer’s Risk for APOE4 Carriers

Mar 23, 2023

“Lifestyle factors, such as exercise, nutrition, sleep, and others, can temper some of the risks associated with carrying APOE4. This Aliquot focuses on the ones that can have the greatest benefits – and the ones that do the most harm.”

aliquot nutrition exercise alzheimer's
Duration: 52m 27s
82
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Aliquot #87: Advanced glycation end-products (AGEs) – byproducts of glucose metabolism that promote aging

Apr 29, 2023

“Advanced glycation end-products, or AGEs for short, are created when the sugars, amino acids, and fats in food encounter heat. AGEs also form in the body during normal glucose metabolism. However, if high levels of AGEs accumulate in the tissues and blood, they can become pathogenic.”

aliquot diet aging metabolism
Duration: 19m 19s
83
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Aliquot #96: Thermal Stress, Part I: The Science Behind Heat Stress and its Positive Effects on Health

Oct 22, 2023

Hormesis is a compensatory defense response to a stressor that conditions the body against future stressors. Heat exposure – from sauna use, hot tubs, or eve...

aliquot aging metabolism heat stress
Duration: 43m
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What Alpha-Lipoic Acid May Do for Metabolic Health

Nov 18, 2024

“A four-week pilot study in people with type 2 diabetes reported improved insulin-stimulated glucose disposal after oral alpha-lipoic acid, while a three-week randomized trial found that intravenous 600 milligrams per day reduced diabetic neuropathy symptoms.”

supplements brain metabolism insulin resistance
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85
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Ancient practices as a treatment for depression: fasting, sweat lodges & long-distance running

Aug 28, 2019

“While sanitation and clean drinking water are critical to survival, the over sterilization of our environment may play a role in modulating the human immune system. In this clip, Dr. Charles Raison highlights how ancient practices such as heat exposure, long-distance running, and fasting may promote well-being in the modern world.”

depression exercise fasting immune system
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86
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Episode

Dr. Andy Galpin: The Optimal Diet, Supplement, & Recovery Protocol for Peak Performance

Apr 28, 2025

“According to the latest research on fed vs. fasted exercise: If your workout lasts longer than 60 minutes, especially aerobic (endurance-based) sessions, eating beforehand tends to improve performance Your body has quick access to glucose, which helps you go longer and harder.”

exercise supplements nutrition sleep
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APOE4 gene and associated risk for Alzheimer's disease | Dale Bredesen

Jul 12, 2019

“Approximately 25 percent of people in the United States – roughly 75 million people – carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”

alzheimer's brain metabolism inflammation
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Can someone with an APOE4 genotype follow a ketogenic diet? | Dominic D'Agostino

May 17, 2022

“The ketogenic diet is contraindicated in people with pancreatitis, fat metabolism disorders, and other rare metabolic conditions. Some people carry a version of the apolipoprotein E gene called APOE4 – a risk factor for late-onset Alzheimer's disease.”

ketogenic diet alzheimer's diet metabolism
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How Sleep, Diet, Exercise, and Mental Health Fit a Longevity Routine

Dec 27, 2023

“He reserves melatonin and phosphatidylserine for jet lag. He presents these as his personal practices. Dr. Attia also reports drinking anywhere from zero to seven or eight alcoholic drinks per week, no more than two in a day and usually with dinner.”

mental health exercise diet sleep
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90
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Episode

Sauna Use and Building Resilience to Stress with Dr. Rhonda Patrick

Jan 3, 2016

“- Practical details like temperature and duration of sauna use, the difference between a dry, wet and infrared sauna, sauna timing, as well as other forms of heat stress such as steam showers, hot baths, and hot yoga.”

heat stress exercise brain aging
Play episode Duration: 1h 4m 57s
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