Related Episodes for Ultra-processed Foods (UPFs)

“Whereas fasting turns off multiple pathways associated with aging, such as mTOR and IGF-1, eating for optimal fitness activates these important processes. The IGF-1 pathway, in particular, plays key roles in growth and is strongly associated with cancer.”

“In eight young men, seven days of 1,000 milligrams of NR per day changed selected muscle NAD metabolites but did not alter substrate use, mitochondrial respiration, or signaling involved in adaptation to one hour of endurance exercise.”

“Melatonin appears in the comparison as a personal, goal-specific choice rather than a universal nightly supplement. Dr. Patrick also discusses glycine, collagen, myo-inositol, and other non-overlapping items with different levels of evidence.”

“A separate trial of 153 adults found that smartphone-based mindfulness training combining attention monitoring with acceptance reduced daily loneliness and increased social interactions compared with monitoring alone or an active control.”

“There's a lot of exciting research right now into aging and maximum lifespan, but scientists have really just scratched the surface of the fascinating topic of how to live longer, healthier lives. Relevant Publications Rootzén, Holger, and Dmitrii Zholud.”

“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”

“Insulin-like growth factor 1 (IGF-1) plays a role during childhood for growth and continues later in life to have anabolic and neurotrophic effects. IGF-1 is also implicated in contributing to aging and enhancing the growth of cancer after it has been initiated.”

“If we eat carbohydrate-containing foods when melatonin levels are high, our pancreas cannot produce the insulin needed to use the glucose. Therefore, eating too close to bedtime or immediately upon waking, before nightly melatonin levels have declined, may hamper the body's ability to process glucose.”

“A preliminary study shows atrophy in olfactory brain regions and areas responsible for learning and memory, after COVID-19 illness, even in those with mild cases. Converging evidence suggests that the long-term impacts of SARS-CoV-2 infection are unknown.”

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”