Related Episodes for APOE 3/4 and APOB and their influence on Alzheimer’s and cardiovascular disease | Peter Attia

“Dr. Patrick explains some of the early evidence that suggests the value prolonged fasting (48+ hours) may have from the standpoint of tissue rejuvenation and healthspan maintenance, as well as relevance for other more specific conditions.”

“In this clip, Dr. Valter Longo discusses the origin of the fasting-mimicking diet and a possible future which may lean away from a drug-centered mentality to one which allows the body to heal itself.”

“In REDUCE-IT, prescription icosapent ethyl lowered major ischemic events among statin-treated adults with elevated triglycerides, while atrial fibrillation or flutter requiring hospitalization occurred more often in the treatment group.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“How too much iron can lead to protein aggregation and how vitamin D can prevent it. A program, directed by Gordon, called the Caenorhabditis Intervention Testing Program which tests potential longevity compounds that may extend the lifespan of several different species of worms.”

“In this clip from Dr. Rhonda Patrick's appearance on The Mel Robbins Podcast, she outlines a practical sleep audit built around adequate sleep, morning light, regular timing, earlier meals, and alcohol awareness.”

“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”

“Earlier long-term research in older male physicians found no cognitive benefit, and the main COSMOS trial did not significantly reduce invasive cancer, cardiovascular events, or mortality over a median of 3.6 years.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spread across 8.5 hours reduced post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“Exposure to bright light also promotes the release of cortisol, and, in turn, the hormone drives wakefulness during the daytime hours. Chronic stress and mis-timed exposure to light can dysregulate cortisol release and promote aging, however.”