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“Berberine is a plant-derived compound that may be beneficial for treating a wide range of chronic health conditions associated with obesity, such as hypertension, dyslipidemia, and type 2 diabetes, among others.”

“A four-week pilot study in people with type 2 diabetes reported improved insulin-stimulated glucose disposal after oral alpha-lipoic acid, while a three-week randomized trial found that intravenous 600 milligrams per day reduced diabetic neuropathy symptoms.”

“Animal studies indicate that omega-3 deficiency may also reduce GLUT1 transporters in the brain. Other studies suggest that omega-3 supplementation reduces VCAM1 levels – a protein elevated with normal aging, which could be related to the breakdown of the blood-brain barrier.”

“Approximately 25 percent of people living in the United States carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”

“Approximately 25 percent of people in the United States – roughly 75 million people – carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”

“- Arthur Brooks, Ph.D. The episode closes with a framework from Brooks's work on the second half of life: jump, serve, worship, and connect, a framework he outlines in one of his earlier books, From Strength to Strength: "Jump" means proactively building the next thing, especially during liminal periods or unwelcome change, which Brooks sees as fertile ground for creativity.”

“Microbial responses to individual components of a person's diet may influence host health. Food ingredients, such as artificial sweeteners and dietary emulsifiers, are typically thought to be inert, however, recent evidence suggests they impact gut microbes, ultimately influencing human health.”

“Since a driving force in the development of insomnia is change, especially change that affects relationships, employment, or family dynamics, Dr. Mason employs cognitive behavior techniques that help her patients identify what those changes are and develop strategies that promote, rather than hinder, sleep.”

“Practicing the skills they acquire with resources available in the community — a personal trainer or a group class will allow them to reap the benefits of exercise. People are encouraged to try a variety of activities, which can improve their enjoyment and compliance.”

“Another study suggests that intermittent fasting combined with exercise training increased serum ketone levels, increased the number of mitochondria in muscle cells, and improved endurance. In this clip, Dr. Mark Mattson describes how fasting and exercise work together to promote brain health.”