Related Episodes for Dr. Dominic D'Agostino on Developing a Well-Designed Ketogenic Diet and Harnessing its Benefits

“Severe sleep deprivation offers one such model. In a randomized crossover study of 15 healthy young adults, a single dose of 0.35 grams per kilogram changed brain-energy measures and reduced deterioration on selected cognitive tasks during about 21 hours awake.”

“High energy demand is a promising research setting. In a randomized crossover study of 15 healthy adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed cerebral energy measures and improved selected cognitive outcomes.”

“A systematic review in older adults linked Mediterranean dietary patterns with lower inflammatory markers, while a meta-analysis of randomized trials found that vitamin D supplementation reduced acute respiratory infection risk overall, with the strongest protection among people who were very deficient and received regular doses.”

“A meta-analysis of seven randomized trials involving 182 participants found that high-intensity interval training improved flow-mediated dilation by 4.31%, compared with 2.15% after moderate-intensity continuous training, with a 2.26-percentage-point advantage between groups.”

“She uses that result to make consistency practical. Aerobic exercise does not need to be all-out every day, but sessions that raise heart rate and improve cardiorespiratory fitness provide a meaningful brain stimulus.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spaced every 45 minutes across 8.5 hours lowered post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“In a study of more than 25,000 UK Biobank adults who reported no structured exercise, about three short VILPA bouts per day were associated with 38 to 40 percent lower all-cause and cancer mortality and 48 to 49 percent lower cardiovascular mortality compared with no VILPA.”

“In 15 people with severe traumatic brain injury, sodium lactate infusion increased brain lactate, pyruvate, and glucose without raising intracranial pressure, and a randomized study in 60 patients with mild traumatic brain injury reported better cognitive recovery than hypertonic saline.”

“In this clip from Dr. Rhonda Patrick's appearance on Katie Couric's Next Question, she explains why magnesium supports both immediate energy needs and long-term cellular maintenance. Magnesium serves as a cofactor for more than 300 enzymes and helps maintain DNA structure, replication, and repair systems.”

“Mouse studies of feeding during infection also found different responses across bacterial and viral models, so a minimally processed dietary pattern, regular exercise, and normal hydration and nutrition during illness provide a more useful foundation than one universal food or fasting rule.”