Related Episodes for How Coffee Supports Healthy Aging

“Preliminary findings from a study analyzing UK Biobank data with over 25,000 participants suggest that even 3-4 minutes of VILPA daily could reduce all-cause mortality risk by 25-30%.”

“Longer-term nutrient status offers another perspective: in a randomized trial of adults with overweight or obesity, 15 grams of psyllium daily for three months did not significantly alter serum micronutrient concentrations relative to control.”

“In a six-month trial of adults with peripheral artery disease, a flavanol-rich cocoa beverage improved six-minute walking distance measured 2.5 hours after dosing. In older adults with mild cognitive impairment, higher-flavanol cocoa improved selected verbal-fluency and executive-function tests over eight weeks.”

“Time-restricted eating, a form of fasting that limits the period during which a person eats to a 12- to 16-hour window, capitalizes on the benefits associated with both fasting and optimization of the body's circadian biology.”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“Perhaps the most clear-cut examples of cryotherapy’s beneficial effects are observed in the brain, where levels of the hormone and neurotransmitter norepinephrine – responsible for vigilance, attention, focus, and positive mood – increase markedly when the body is exposed to extreme cold.”

“However, the term "fasting" can comprise a variety of subtypes. Intermittent fasting, a term lacking specificity, usually refers to interventions such as alternate-day fasting, fasting one day per week, or a five:two eating pattern (fasting for two days per week).”

“The most compelling human signal appears when the brain is under acute strain. In a randomized crossover study, a single dose of 0.35 grams per kilogram during 21 hours of sleep deprivation changed cerebral energy metabolites and preserved selected measures of cognitive performance.”

“A recent meta-analysis also found small benefits in selected cognitive domains, including memory and processing speed, with responses that may depend on age, diet, baseline stores, stress, dose, and the cognitive test used.”

“A separate six-week randomized study in 30 healthy young adults found that neither 10 nor 20 grams per day improved the tested cognitive outcomes compared with placebo. The result is an important counterweight to the acute sleep-deprivation experiment.”