Related Episodes for IGF-1 plays a key role in the regenerative processes activated by prolonged fasting | Valter Longo

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”

“Dr. Patrick describes increased shear as a possible way vigorous exercise can damage fragile circulating tumor cells; this is a proposed mechanism, not proof that a workout eliminates metastasis or treats an established tumor.”

“In this excerpt from Dr. Rhonda Patrick's A4M LongevityFest 2023 keynote, she argues that vigorous exercise is one of the most powerful tools for healthy aging because it can raise cardiorespiratory fitness.”

“In 25,241 adults who reported no structured exercise, a median of three one- or two-minute vigorous lifestyle bouts per day was associated with 38% to 40% lower all-cause and cancer mortality and 48% to 49% lower cardiovascular mortality.”

“Dr. Patrick also describes a proposed anti-metastatic mechanism: faster blood flow during vigorous exercise increases shear forces on circulating tumor cells, the cells that have left a primary tumor and entered the bloodstream.”

“Controlled human studies support acute brain-related responses to high-intensity exercise. Six short all-out cycling intervals improved selected learning and executive measures while increasing circulating BDNF, IGF-1, and VEGF; lactate tracked several of these changes.”

“Gaining FDA approval of psilocybin under these conditions is problematic, however, due to the negative connotations associated with the compound's use and the potential for harm when used in vulnerable populations.”

“People with Parkinson's disease can benefit from engaging in an intense exercise program that incorporates both a skilled and an aerobic component. Activities that involve gait and balance training are particularly useful.”

“How too much iron can lead to protein aggregation and how vitamin D can prevent it. A program, directed by Gordon, called the Caenorhabditis Intervention Testing Program which tests potential longevity compounds that may extend the lifespan of several different species of worms.”

“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”