Related Episodes for Insulin, carbohydrates and the IGF-1 pathway’s role in cancer and aging | Peter Attia

“Antibody-dependent enhancement, or ADE, is a phenomenon that occurs when low quality, low quantity, non-neutralizing antibodies bind to virus particles and, rather than neutralizing the virus, increase inflammation and tissue injury.”

“For people whose ApoB rises on a high-saturated-fat diet, replacing butter, cheese, fatty red meat, coconut oil, and palm oil with olive oil, avocado, nuts, and fish is a practical experiment to review with a clinician.”

“Approximately 25 percent of people in the United States – roughly 75 million people – carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”

“Dr. Krauss explains how some people might be inappropriately prescribed statins while other people should be taking statins. In addition, his current research is investigating whether statins can increase the risk of diabetes, especially for women.”

“Microbial responses to individual components of a person's diet may influence host health. Food ingredients, such as artificial sweeteners and dietary emulsifiers, are typically thought to be inert, however, recent evidence suggests they impact gut microbes, ultimately influencing human health.”

“However, she considers the amounts in its proprietary superfood, extract, and probiotic blends too small to justify expecting the broader benefits implied by those categories. She presents this as her assessment of the product label.”

“Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS Research Foundation which aims to find technologies that can repair the various types of damage that occur during the aging process. Learn more about Dr. Aubrey De Grey SENS Research Foundation.”

“Researchers have determined that beta-hydroxybutyrate is an endogenous regulator of HDACs and is able to regulate age-related genes such as FOXO3. In this clip, Dr. Eric Verdin discusses the role of beta-hydroxybutyrate in protecting against oxidative stress, both as a nutrient, but also as a transcription regulator.”

“For instance, while the U.S. has high obesity rates, its rates of type 2 diabetes remain modest compared to countries like Singapore, India, and many Middle Eastern nations—populations that, on average, tend to have "fatter fat cells" and therefore develop metabolic complications at lower body mass indices (BMIs).”

“Premenopausal females have much lower rates of cardiovascular disease than similarly aged males because of the protective effects of estrogen, but after menopause, there's not much of a difference, and cardiometabolic risk factors actually worsen in females during the menopause transition, indicating this may be a crucial time for exercise intervention to protect the cardiovascular system.”