B-Hydroxybutyrate protects against oxidative stress as a nutrient and as a transcription regulator | Eric Verdin

Parent Episode: Dr. Eric Verdin on Ketogenic Diet Longevity, Beta-Hydroxybutyrate, HDAC Inhibitors & NAD+

Beta-hydroxybutyrate is similar to butyrate, a byproduct of bacterial fermentation in the gut. Butyrate acts as an inhibitor of histone deacetylases (HDACs), which are epigenetic regulators linked to aging. Researchers have determined that beta-hydroxybutyrate is an endogenous regulator of HDACs and is able to regulate age-related genes such as FOXO3. In this clip, Dr. Eric Verdin discusses the role of beta-hydroxybutyrate in protecting against oxidative stress, both as a nutrient, but also as a transcription regulator.

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