Related Episodes for Jim Kean Talks Biomarkers, Building a Spectator Sport

“In this clip from his FoundMyFitness interview with Dr. Rhonda Patrick, Dr. Benjamin Levine explains why recovery is part of training rather than time lost between workouts. Hard sessions trigger protein synthesis, vascular signaling, and muscular remodeling, but those changes need lower-stress time to develop.”

“In a clinical trial, researchers subjected people to three cycles of a fasting-mimicking diet and measured biomarkers including cholesterol, triglycerides, fasting glucose, IGF-1, blood pressure, and C-reactive protein.”

“However, the DNAm GrimAge epigenetic clock is a highly reliable predictor of healthspan and lifespan, based on DNAm surrogates in blood, including biomarkers of aging and alterations in blood composition.”

“The algorithm — based on factors including blood parameters, dietary habits, and gut microbiota — was employed in a clinical trial, where researchers showed that personally tailored diets lowered post-meal blood glucose levels.”

“Studies of physician-AI collaboration show that workflow matters. In one randomized simulated-management trial, physicians using GPT-4 received higher management-reasoning scores than physicians using conventional resources, although they took longer.”

“Cholesterol-lowering drugs can act at several points in the body's handling of lipoproteins. Dr. Rhonda Patrick compares PCSK9 inhibitors, bempedoic acid, and ezetimibe, focusing on how they reduce circulating LDL and apoB-containing particles.”

“In a randomized factorial design, participants were assigned to one gram per day of algae-derived omega-3 or placebo, 2,000 IU of vitamin D3 or placebo, and a 30-minute home strength program three times weekly or a flexibility control.”

“The Endocrine Society recommends aiming for testosterone concentrations in the mid-normal range while choosing an approved formulation based on patient preference, pharmacokinetics, formulation-specific effects, treatment burden, and cost.”

“A pooled analysis of 1,422 participants from 14 intervention trials found that supplemented participants took an average of 1,983 milligrams of EPA plus DHA per day for about 13.6 weeks, while their mean Omega-3 Index rose from 4.9% to 8.1%.”

“Elevated biomarkers of inflammation, which are commonly observed in people who have depression, chronically activate the body's inflammatory response system, promoting the development of depressive symptoms and inducing changes in brain and neuroendocrine function.”