Ranked by shared topics, with one result from each original episode.
“Whereas fasting turns off multiple pathways associated with aging, such as mTOR, IGF-1, growth hormone, and others, eating for optimal fitness activates these important processes. This Aliquot features Drs. Guido Kroemer, Dominic D'Agostino, Valter Longo, Peter Attia, and Rhonda Patrick.”
“Circadian rhythms play key roles in metabolic health and ultimately influence body weight, performance, and susceptibility to diseases like diabetes and cancer. Aligning food intake with circadian rhythms can improve many aspects of metabolic health.”
“A healthy intestinal barrier limits the transport of pathogens and endotoxins from the gut to the bloodstream; however, increased gut permeability (known as "leaky gut") raises endotoxin levels, leading to metabolic endotoxemia.”
“Dietary fiber is a broad term that refers to the non-digestible components of fruits and vegetables. Gut microbes break down certain types of fiber, releasing micronutrients trapped in the fiber matrix and producing beneficial metabolic byproducts, such as short-chain fatty acids.”
“Continuous glucose monitors – CGMs, for short – are wearable devices that measure blood glucose levels through a tiny sensor placed under the skin. The CGM communicates with your smartphone and provides nearly real-time information about your blood glucose levels.”
“Sugar substitutes are food products or additives that provide the sweet taste of sugar, without the calories. Evidence suggests that sugar substitutes have surprising effects on human metabolism and these effects vary person-to-person, based on the overall makeup of an individual's gut microbiome.”
“The benefits of HIIT include improvements in muscle tissue oxidative capacity, enhanced insulin response, improvements in heart function, and increased lactate – an important source of fuel for the heart, brain, and muscles.”
“Late-night eating can have negative effects on our health. But time-restricted eating limits the daytime window during which a person eats to take advantage of the time when metabolism is optimized, improving health and even promoting weight loss.”
“Lifestyle factors, such as exercise, nutrition, sleep, and others, can temper some of the risks associated with carrying APOE4. This Aliquot focuses on the ones that can have the greatest benefits – and the ones that do the most harm.”
“Advanced glycation end-products, or AGEs for short, are created when the sugars, amino acids, and fats in food encounter heat. AGEs also form in the body during normal glucose metabolism. However, if high levels of AGEs accumulate in the tissues and blood, they can become pathogenic.”