Related Episodes for Lifestyle factors that affect Alzheimer’s risk for APOE4 carriers | Peter Attia

“Her practical message is to reduce the frequency and size of large glucose exposures. Foods with intact fiber, protein, and minimally processed carbohydrates digest more slowly than refined added sugar, while regular exercise gives skeletal muscle a large destination for circulating glucose.”

“In animal studies, high doses of magnesium in the form of magnesium L-threonate have been shown to cross the blood-brain barrier readily and coincide with improvements in cognitive function.”

In this clip, Dr. Griffiths talks about the effect of dose on psilocybin mystical experiences and ‘bad trips’.

“00:44:53 - How marine omega-3 fatty acids EPA and DHA may be one of the safest supplements to delay telomere attrition, with each 1-standard deviation increase in levels associated with a 32% reduction in the odds of telomere shortening and how one four-month double-blinded supplementation study showed that omega-3 could even lengthen telomeres.”

“A smaller comparative study found improved hair density, shaft size, and anagen-follicle proportion with 2 percent ketoconazole shampoo, while its authors called for larger controlled studies. These results support individualized combinations rather than one universal protocol.”

“Contrary to the traditional view of lactate as a metabolic waste product, it is now recognized for its critical role in brain health. Elevated lactate levels after vigorous exercise are linked to improved executive function, hinting at its potential protective benefits against neurodegenerative diseases.”

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”

“In this excerpt from Dr. Rhonda Patrick’s A4M LongevityFest 2023 keynote, she reviews a randomized trial in sedentary middle-aged adults. Two years of progressive, supervised aerobic training increased VO2 max and reduced left-ventricular stiffness.”

“Controlled human studies support acute brain-related responses to high-intensity exercise. Six short all-out cycling intervals improved selected learning and executive measures while increasing circulating BDNF, IGF-1, and VEGF; lactate tracked several of these changes.”

“In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging. Dr. Levine also discusses the aging clock she created and how it can be used, along with other biomarkers, to determine an individual's rate of aging.”