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“In a small trial involving adults with obesity, a ketone monoester improved one processing-speed task and selected brain blood-flow measures, providing an early signal for further research. Temperature can also shape alertness and sleep preparation.”

Dr. Ronald Krauss discusses the role that LDL cholesterol plays in heart disease, dyslipidemia, and atherosclerosis.

“Small controlled trials of early time-restricted eating, which included breakfast and moved dinner earlier rather than testing breakfast skipping, found improved insulin sensitivity in eight men with prediabetes and lower 24-hour glucose in 11 adults with overweight.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”

“Supplementation trials answer a different practical question: in VITAL, 1 gram of marine omega-3s daily did not significantly reduce the primary cardiovascular composite over 5.3 years, although total heart attacks were lower as a secondary outcome.”

“In a controlled five-week crossover trial involving men with prediabetes, an early six-hour eating window with dinner before 3 p.m. improved insulin sensitivity, pancreatic beta-cell responsiveness, blood pressure, oxidative stress, and appetite without causing weight loss.”