Related Episodes for Meditation changes gene expression and has long-term benefits | Roland Griffiths

“Exercise is a huge driver of how well we age because it induces profound molecular shifts that support immune health and might even protect our telomeres – indicators of aging. Exercise might help forestall certain age-related diseases, such as Parkinson's disease, too.”

“Roughly one-quarter of people living in the US carry a genetic variant of the apolipoprotein E gene, called APOE4, the most important genetic risk factor for Alzheimer's disease. Many lifestyle behaviors can mitigate risk, especially sleep hygiene, which provides an opportunity to rid the brain of toxic metabolic byproducts that can contribute to Alzheimer's disease risk.”

“Individual responses to diet can be influenced by a person's genetic makeup, however. Knowing a person's genetic factors influencing their response to diet may be beneficial component of a multi-part strategy developed in coordination with professional care for keeping ApoB in check.”

“Lifestyle factors, such as exercise, nutrition, sleep, and others, can temper some of the risks associated with carrying APOE4. This Aliquot focuses on the ones that can have the greatest benefits – and the ones that do the most harm.”

“Vascular dysfunction, the loss of normal endothelial tone and permeability of blood vessels, is a common feature of most forms of dementia, including Alzheimer's disease. People who carry the APOE4 gene are at greater risk for vascular dysfunction and Alzheimer's disease.”

“Disruption of a person’s chronotypic schedule can influence mood, productivity, and disease risk because it may interfere with the duration of their REM sleep, which is essential for emotional well-being.”

“If you have used a consumer genetic testing service like 23andMe or AncestryDNA and want to learn more about whether or not the data indicates your specific genotype on these SNPs, check out our free viral report here.”

“Manipulation of cellular levels of NAD+ as a strategy for slowing aging "We’ve shown that NMN and others have shown for NR that it also helps with blood flow and actually mimics exercise and regrows the vascular system.” - David Sinclair, Ph.D. As we age, however, the NAD+ levels in our bodies decline, reducing resveratrol's potency.”

“Genetic factors can impact plasma lipoprotein levels and the risk of coronary artery disease. Genes associated with elevated low-density lipoprotein (LDL) cholesterol levels have also been associated with increased heart disease risk, suggesting a causal relationship.”

“While some forms of Parkinson's disease are genetic, most cases involve a complex interaction between genetic and environmental risk factors. In the early 1980s, intravenous drug users inadvertently injected a contaminated drug and developed parkinsonian symptoms overnight.”