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Related Episodes for MTHFR gene and supplementation with 5-L-methylfolate | Tim Ferriss

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1
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Aliquot #134: Why Homocysteine Accelerates Brain Aging

Sep 11, 2025

“In this Aliquot, I explain exactly what homocysteine is, how it impacts both cardiovascular and brain health, and how simple nutritional strategies—like supplementing with vitamins B6, B12, and methylfolate—can help bring levels down, supporting healthy aging and sharper cognitive function.”

vitamin b12 heart disease folate nitric oxide
Duration: 19m 39s
2
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Clip

How folate deficiency leads to DNA damage similar to being irradiated | Bruce Ames

Apr 6, 2022

“In this clip, Bruce Ames describes how folate is critical for the transferring of single-carbon groups between molecules. A deficiency in folate leads to errors in production of nucleic acids and can lead to double-stranded breaks in DNA.”

vitamin d aging dna damage folate
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3
Episode
Episode

Nutrigenomics, Epigenetics, and Stress Tolerance (IHMC Talk #1)

Nov 8, 2017

“In this talk, we’ll be exploring the intersection between genetics, nutrition, and environment: how your diet, micronutrients, exercise, heat stress, and sleep can change the expression of your genes and how this has profound effects on the way your body functions and ages.”

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4
Q&A
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Q&A #69: Should You Take Low-Dose Lithium—and How Can You Lower Homocysteine?

May 6, 2025

Dr. Rhonda Patrick covers lithium microdosing, reducing homocysteine, aluminum's link to cancer, and beta-alanine and alpha-lipoic acid supplements.

exercise biomarkers vitamin e genetics
5
Q&A
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Q&A #77: What’s the Best Time to Exercise?—Morning vs. Evening and How to Sequence Sauna and Cold

Feb 3, 2026

Dr. Rhonda Patrick discusses supplement timing, exercise timing, supplements in older adults, folic acid vs. folate, and hydrogen-rich water.

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Why Some Gray Hairs May Regain Pigment

Dec 10, 2024

“Most common graying is strongly related to age and genetics, but selected observations suggest that stress, nutrient status, and cellular energy metabolism can influence pigment in some circumstances.”

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7
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When Buying Organic Matters and Why Eating Produce Still Comes First

Apr 26, 2024

“Dr. Patrick uses skin thickness as a simple buying framework: thin-skinned produce such as strawberries and apples receives more priority for organic purchasing than avocados, bananas, or oranges with peels that are removed.”

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8
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How Daily Habits Shape Cancer Risk

May 23, 2025

“In this clip from Q&A #70, Dr. Rhonda Patrick organizes cancer prevention around the largest modifiable foundations: avoid tobacco, maintain a healthy body composition, and stay physically active.”

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9
Episode
Episode

3 Mechanisms for Magnesium Deficiency

May 16, 2014

“In a previous episode, entitled "Maximizing Your Mitochondria with Magnesium," we learned that 45% of the US population is deficient in magnesium and the important role magnesium plays in mitochondrial function and how this relates to exercise performance by ensuring your muscle cells have the highest oxidative capacity (ability to produce ATP or "energy") possible.”

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10
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How Supplements May Support Brain Health With Age

Aug 6, 2025

“In this clip from Dr. Rhonda Patrick's appearance on The Tim Ferriss Show, she describes the supplements her parents use and separates a simple nutritional baseline from choices tied to individual health needs.”

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