Related Episodes for Ray Cronise on Cold Thermogenesis, Intermittent Fasting, Weight Loss & Healthspan

“Scientists are investigating the effects that Wim Hof's breathing methods have on the immune system. Study results showed that individuals trained in his breathing practices produced adrenaline when injected with a bacterial endotoxin, potentially affecting the immune response.”

“Timing provides a practical compromise. Dr. van Loon favors protecting the first several hours after resistance or endurance training, then placing cold exposure later in the day or on a recovery day when muscle adaptation is the priority.”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“Perhaps the most clear-cut examples of cryotherapy’s beneficial effects are observed in the brain, where levels of the hormone and neurotransmitter norepinephrine – responsible for vigilance, attention, focus, and positive mood – increase markedly when the body is exposed to extreme cold.”

“Dr. Huberman therefore uses a subjective ‘wall’ model rather than a rigid prescription: enter safely, notice the first strong urge to leave, and practice staying calm long enough to complete the planned exposure.”

“Timing matters when cold exposure follows resistance training. In a 12-week study of 21 men, ten minutes of cold-water immersion immediately after each session attenuated gains in strength and muscle mass and reduced selected anabolic signals.”

“A systematic review found no overall improvement in mood after cold-water immersion, while a small randomized trial found that repeated whole-body cryotherapy improved depression scores when added to standard pharmacological treatment.”

“A special focus of this podcast, however, centers on Pierre's relationship with previous podcast guest Wim Hof, who is especially well-known for his extraordinary ability to withstand extreme cold, taking on many world records by doing so.”

“Cognitive enhancement is a hot topic, but the best ways to sharpen focus, boost motivation, and support brain health aren't always clear-cut. Stimulants like nicotine and caffeine offer immediate benefits but come with trade-offs—some minor, others riskier.”

“These changes increase infection risk, weaken vaccine responses, and reduce early cancer surveillance. Yet immune aging is not fixed. Movement, sleep, stress regulation, temperature exposure, and nutrition shape immune cell balance and inflammatory activity over time.”