Related Episodes for How Sleep Loss Disrupts Glucose Regulation

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”

“One of the mechanisms behind the beneficial effects of exercise is its ability to induce autophagy in skeletal muscle and, potentially, other organs. In this clip, Dr. Guido Kroemer describes the anti-diabetes and anti-obesity effects of exercise-induced autophagy.”

“The physical activity guidelines and estimates on how much activity we need are heavily based on self-reported activity, which is useful but imperfect: people remember going for a run, but they forget the short, intense bursts in daily life like sprinting up stairs, chasing kids, and running to catch a bus.”

“Wearable-device research in more than 25,000 adults who reported no structured exercise linked about three one- to two-minute vigorous bouts per day with substantially lower all-cause, cardiovascular, and cancer mortality.”

“In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging. Dr. Levine also discusses the aging clock she created and how it can be used, along with other biomarkers, to determine an individual's rate of aging.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“In this clip from his FoundMyFitness interview with Dr. Rhonda Patrick, Dr. Derya Unutmaz presents an optimistic vision in which AI, biotechnology, and rapidly improving treatments help more people remain healthy long enough to benefit from the next generation of therapies.”

“During about eight years of follow-up, the models associated one vigorous minute with roughly 4.1 moderate minutes for all-cause mortality, 7.8 minutes for cardiovascular mortality, and 9.4 minutes for type 2 diabetes risk.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spaced every 45 minutes across 8.5 hours lowered post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“In eight young men, seven days of 1,000 milligrams of NR per day changed selected muscle NAD metabolites but did not alter substrate use, mitochondrial respiration, or signaling involved in adaptation to one hour of endurance exercise.”