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“Diet plays a key role in the prevention of Alzheimer's disease. The Ketoflex 12/3 diet, a form of time-restrictive eating that limits the period during which a person eats to a 12-hour window at least three hours before bedtime, promotes the production of ketones.”

“Time-restricted eating can help some people reduce eating opportunities, but controlled trials have not found a consistent visceral-fat advantage over matched dietary counseling or calorie restriction.”

“Time-restricted eating – a term coined by Dr. Panda and his colleagues – has been adopted by the popular press as a form of intermittent fasting. It does not explicitly involve reducing calories but rather is an eating pattern wherein a person confines the time of day that they eat to a limited window and fasts for the remainder of the day.”

“Time-restricted eating, in particular, has the potential to realign the body's circadian rhythms. In this clip, Dr. Rhonda Patrick describes some of the different types of fasting and identifies the advantages associated with each.”

“In a four-month randomized trial of 88 overweight, untrained middle-aged adults, daily doses of 500 or 1,000 milligrams improved some muscle and mitochondrial measures, while the primary outcome of peak power did not significantly improve.”

“In a small crossover trial involving people with insulin resistance, six one-minute intense intervals performed before the three main meals improved daily glucose control compared with one continuous 30-minute session.”

“Controlled studies have found higher overnight glucose after an identical dinner eaten at 10 PM instead of 6 PM and a larger glucose response when food intake occurs close to habitual bedtime during elevated endogenous melatonin.”

“Mitochondria are best known for their energy-producing roles, but they also help regulate cellular metabolism, signaling, and apoptosis (programmed cell death). As a result, mitochondrial health is intrinsically linked to overall health.”

“Mitochondrial health and overall health are intrinsically linked. Identifying ways to boost mitochondrial biogenesis – the formation of new mitochondria – ensures that cells maintain an adequate number of mitochondria to meet their energy needs.”

“In this Aliquot, I walk through how that plays out in humans, where the strongest evidence shows up, and where it doesn't, with NAD researcher Dr. Charles Brenner—and why I'm taking it now after being skeptical.”