Search results for lactate

“In this Aliquot, Dr. George Brooks – who identified the lactate shuttle – Dr. Martin Gibala, and I discuss how lactate supports healthy brain function and enhances cognitive performance.”

“In this clip from Dr. Rhonda Patrick's appearance on CrossFit Podcast, she explains why lactate is more than a waste product. Vigorous exercise rapidly increases lactate production, giving working tissues and the brain another fuel source while also participating in cellular signaling.”

“Animal experiments show that exercise-derived lactate can cross the blood-brain barrier and activate hippocampal BDNF signaling involved in learning and memory. Human studies connect higher-intensity exercise, lactate, and neurotrophic responses.”

“Within the brain, glycolytic astrocytes produce lactate that neurons can import and use as fuel. Using lactate can spare glucose for the pentose-phosphate pathway, which produces NADPH needed to regenerate glutathione.”

“The myth was born, and it perpetuates today among coaches, athletes, and just about everyone else. However, these dated ideas run counter to new evidence that suggests oral intake of lactate actively improves exercise performance.”

“Glutathione helps prevent damage from oxidative stress caused by the production of reactive oxygen species that can occur after a traumatic brain injury. In this clip, Dr. Dominic D'Agostino discusses the neuroprotective potential associated with a combination of ketones and lactate in the management of traumatic brain injury.”

“A growing body of evidence suggests that exogenous lactate or beta-hydroxybutyrate may be useful in the treatment of traumatic brain injury. These compounds allow glucose to be spared as an energy source and instead be utilized in the synthesis of the antioxidant glutathione, which is vital following a brain injury.”

“Astrocytes, star-shaped cells found in the brain and spinal cord, use glucose to generate lactate, which is then utilized by neurons. In addition, exercise preferentially causes the brain to take up lactate.”

“Among its other signaling effects, lactate increases GLUT4 transporters in skeletal muscle, allowing for a greater amount of glucose uptake. This effect lasts for up to 48 hours, with the first 24 hours representing the most robust period of enhanced glucose control.”