What FoundMyFitness Has Covered
PremiumTNF-alpha is a pro-inflammatory cytokine involved in systemic and brain-related inflammatory signaling. Elevated TNF-alpha commonly accompanies depression and is associated with depressive symptoms and changes in brain and neuroendocrine function; in mice with liver disease, brain…
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Caloric restriction
“"Those who attempted a 25% calorie-restricted diet for two years resulted in lower total cholesterol, LDL-cholesterol, triglycerides, C-reactive protein, TNF-alpha, and blood pressure even though they only were able to achieve 12% calorie-restriction.".”
Toll-like receptors
“Elevated biomarkers of inflammation, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), are commonly observed in people with depression. These pro-inflammatory cytokines coincide with the development of depressive symptoms and induce changes in the brain and neuroendocrine function.”
Cold exposure
“Elite tennis players who engaged in whole-body cryotherapy had decreases in the pro-inflammatory cytokine TNF-alpha and increases in IL-6, which exhibits both pro- and anti-inflammatory properties and plays a role in muscle repair.”
Quercetin
“Researchers investigated quercetin's capacity to decrease CRP, interleukin (IL)-6, and tumor necrosis factor-alpha (TNF-alpha). Analysis of six studies involving 348 participants revealed that quercetin reduced CRP in those over the age of 40 years, as well as those who had been diagnosed with a disease.”
TNF-alpha production within the brain may partially explain the behavioral changes in mice with cholestatic liver damage. (2006)
“In turn, the immune cells increased their production of TNF-alpha. In light of the known effects of TNF-alpha on sickness behaviors, these findings suggest that TNF-alpha production in the brain mediates sickness behaviors in mice with liver disease.”
Probiotics may improve inflammation-associated behavioral changes in mice by lowering TNF-alpha blood levels. (2015)
“Mice that received the probiotics also had lower TNF-alpha levels and fewer activated immune cells in their brains compared to mice that received a placebo. These findings suggest that probiotics attenuate inflammation-associated sickness behaviors in mice, likely via modulation of the gut-brain axis.”
Serotonin 5-HT2A receptor activation (molecular target of classical psychedelics) suppresses TNF-alpha-induced inflammation with extraordinary potency
“FTA: > We have now discovered that activation of 5-HT(2A) receptors in primary aortic smooth muscle cells provides a previously unknown and extremely potent inhibition of tumor necrosis factor (TNF)-alpha-mediated inflammation. [...] With the exception of a few natural toxins, no current drugs or small molecule therapeutics demonstrate a comparable potency for any physiological effect”
Omega-3 fatty acids
“Participants also provided blood and saliva samples as a means to measure cortisol (a stress hormone), telomerase; anti-inflammatory cytokines, including interleukin (IL)-10 (IL-10); and proinflammatory cytokines, including IL-6, IL-12, and tumor necrosis factor-alpha (TNF-alpha).”
Red light therapy (photobiomodulation)
“In addition, the red LED light altered the levels and activation of proteins involved in TRPV4/PI3K/AKT/mTOR – a TNF-alpha-triggered signaling pathway involved in cell growth, movement, and inflammation.”
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