Search results for insulin

“How the anti-depressant effects of whole-body hyperthermia may actually intimately depend on the spike in IL-6. The role IL-6 plays as a myokine by conferring beneficial metabolic adaptations in response to exercise, including increased insulin sensitivity.”

“Insulin-like growth factor 1 (IGF-1) plays a role during childhood for growth and continues later in life to have anabolic and neurotrophic effects. IGF-1 is also implicated in contributing to aging and enhancing the growth of cancer after it has been initiated.”

“The exact fasting trial did not improve its primary insulin-sensitivity measure or measured sleep, while broader controlled studies show that sleep responses to time-restricted eating can differ across protocols and populations.”

“In a crossover study of 845 adults, a glucose load one hour before habitual bedtime produced a higher glucose response and a lower insulin response than the same load four hours before bedtime. Meal timing also changes overnight metabolism.”

“Mammalian target of rapamycin (mTOR) and insulin-like growth factor-1 (IGF-1) are proteins that play critical roles in two major growth pathways in the human body. The intake of amino acids regulates these two pathways, which must remain in balance to facilitate muscle growth and repair.”

“Metformin inhibits mitochondrial adaptations and improvements in cardiorespiratory fitness after aerobic exercise training in older adults. Metformin also diminished whole-body insulin sensitivity after aerobic exercise. Metformin did not diminish the improvements in HbA1c, fasting insulin, 24‐hr mean glucose, and fat mass or the increase in skeletal muscle telomere length after exercise.”

“Exercise promotes the release of insulin-like growth factor-1 and its downstream targets, growth hormone and brain-derived neurotrophic factor, to drive muscle and neuron growth. Sauna use increases these factors, too, and when used post-exercise, may have a synergistic effect to improve cardiovascular, musculoskeletal, and neurological health.”

“Intravenous endotoxin temporarily worsened mood in healthy volunteers, showing one pathway through which a substantial immune challenge can influence the brain. Post-meal sleepiness and ordinary brain fog are more complex and can also involve meal size, circadian timing, glucose and insulin dynamics, sleep loss, and other factors.”

“Overweight/obese people with low inflammation that ate the bar showed weight loss after 8 weeks, raised their HDL, lowered triglycerides and small LDL particles, and improved insulin sensitivity.”

“FOXO1 binds to insulin-response elements to increase hepatic gluconeogenesis, a robust contributor to hyperglycemia in the setting of diabetes. FOXO1 represses PPARγ1 and PPARγ2 promoter activity, driving insulin resistance.”