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How Protein Dose and Timing Shape Muscle Protein Synthesis
Dr. Luc van Loon explains hospital fasting, breakfast, TRE, energy restriction, exercise sensitization, and protein priorities.
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Dr. Luc van Loon explains hospital fasting, breakfast, TRE, energy restriction, exercise sensitization, and protein priorities.
“Nutrient sensing pathways are commonly dysregulated in aging but may be enhanced via dietary interventions, such as calorie restriction and intermittent fasting. Learn more about the beneficial metabolic effects of intermittent fasting in this episode featuring Dr. Mark Mattson.”
“Fasting glucose concentrations among unhealthy patients who supplemented with zinc decreased by 8.8 milligrams per deciliter compared to controls. The studies with healthy people found no significant effect of zinc supplementation on fasting blood glucose.”
“Clips and episodes Polyphenol-rich diets may prolong lifespan. Resveratrol, a polyphenol in grapes, mimics some of the effects of fasting (Mark Mattson interview). Resveratrol's effects on the cardiovascular system (David Sinclair interview).”
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“In both the general population and a group of breast cancer survivors, women who practiced a longer fasting window had lower hemoglobin A1C levels. Women who finished eating earlier in the evening exhibited diminished inflammation as compared to those who fasted the same amount of time but finished eating later.”
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“Dr. Mattson contends that unstressed cells become complacent, making them more vulnerable to the stressors that cause disease, including oxidative stress and inflammation. In modern times, fasting and exercise are behaviors that mildly stress cells.”
“Glucose and triglyceride levels rose significantly across breakfast, lunch, and dinner even though fasting blood glucose levels dropped on days 1–3. Poorer glycemic control appeared to be the most pronounced at breakfast.”
“Ketone production occurs during periods of low food intake (fasting), ketogenic diets, starvation, or prolonged intense exercise. There are three types of ketones produced in the body: acetoacetate, beta-hydroxybutyrate, and acetone.”
“When cellular energy levels are low, such as during exercising, fasting, or caloric restriction, cellular NAD+ levels rise, and the ratio of NAD+ to its reduced form, NADH, increases, thereby serving as a "sensor" to turn on energy-generating pathways and activate enzymes such as sirtuins.”
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“How a special class of enzymes called sirtuins, also known to be activated by caloric restriction and caloric restriction mimetic resveratrol, is tightly correlated with the level of NAD+ and how this "energetic currency" rises in response to fasting.”
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