Search results for metabolism

“Altering the metabolic fate of kynurenine Kynurenine is pivotal to the tryptophan metabolism pathway because it can be converted into the neuroprotective agent kynurenic acid or to the neurotoxic agent quinolinic acid, the latter of which has been implicated in many disorders, including depression.”

“Ray talks about shifting one's perspective from looking at nutrition only through the lens of meeting day-to-day nutritional needs, and instead, also considering optimizing metabolism for longer-term effects as well, the importance of thinking about longevity in the context of functional healthspan, some of the similarities between the body’s physiological response to heat stress, cold stress…”

“From the article: > The Salford team recently showed Vitamin C to be up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG [an inhibitor of glycolysis], but they say that when Vitamin C is combined with an antibiotic, it is up to ten times more effective, making it nearly 100 times more effective than 2-DG.”

“Acutely, Nam had the strongest transient effect on the whole‐blood NAD metabolome, consistent with fast absorption/metabolism. Ex vivo fermentation suggested NR and NMN generate nicotinic acid (NA) and selectively enhance microbial growth/metabolism.”

“Dr. Longo has made huge contributions to the field of aging, including the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases.”

“In a four-month randomized trial of 88 overweight, untrained middle-aged adults, daily doses of 500 or 1,000 milligrams improved some muscle and mitochondrial measures, while the primary outcome of peak power did not significantly improve.”

“Gene polymorphisms, small changes in an organism's DNA sequence, can affect the absorption and metabolism of nutrients, including vitamins and minerals. A polymorphism in the MTHFR gene that decreases enzyme activity leads to inefficient folate metabolism.”

“Regular exercise can improve insulin sensitivity and reduce visceral and liver fat, making sustainable food quality, energy balance, physical activity, and sleep practical long-term targets for metabolic health.”