Search results for genetics

“According to NHANES data, older adults were 63 % more likely to have vitamin D deficiency and 46 % more likely to have vitamin D insufficiency than young adults while other sources have suggested a 70-year-old may produce 4 times less vitamin D than their former 20-year-old selves.”

“Another pilot clinical study finds sulforaphane (abundant in broccoli sprouts and other cruciferous vegetables) increased blood glutathione levels and this correlated with increased glutathione in certain brain regions in healthy people. Sulforaphane is one of the strongest inducers of the Nrf2 genetic pathway which activates genes involved in glutathione production.”

“The most notable of these is APOE, suggesting that in addition to contributing to genetic risk, the protein may play an active mechanistic role in driving disease progression in people with Alzheimer's disease.”

“They tested the animals' cognitive function and measured markers of inflammation and immune activation. Both groups of mice became obese on the high-fat diet, but cognitive tests revealed that the mice without beige fat showed signs of early cognitive impairment while the normal mice did not.”

“Previous work by the Evans lab into a gene called PPAR delta (PPARD) offered intriguing clues: mice genetically engineered to have permanently activated PPARD became long-distance runners who were resistant to weight gain and highly responsive to insulin -- all qualities associated with physical fitness.”

“Using CRISPR-Cas9, a powerful gene editing tool, researchers modified living tumor cells so that they would secrete interferon-beta and granulocyte-macrophage colony-stimulating factor – two potent immunomodulatory and anti-tumor agents.”

“However, volume losses in women manifested a decade later, between ages 65 and 74. These patterns were evident regardless of whether participants carried the APOE4 gene, a key genetic risk factor for Alzheimer's disease.”

“Researchers collected fecal samples from 88 healthy children between the ages of 2 and 14 and used genetic sequencing to analyze the composition of their gut microbial populations.”

“To develop this model, researchers analyzed DNA methylation, a chemical modification that regulates gene activity and changes with age. They studied male-specific DNA methylation patterns in sheep and mice, identifying genetic sites that gradually lost methylation in males while remaining stable in females.”

“Employing genetic techniques, the researchers selectively inhibited or enhanced autophagy in a region of the brain called the lateral habenula and then monitored how the animals reacted to stress. They found that acute stress activated autophagy, while chronic stress inhibited it.”