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“In light of the fact that we now know the body's immune system is afforded direct access to the brain via a network of lymphatic vessels in the meninges, it puts managing systemic inflammation in a whole new light.”

“Participants who often or most days played a musical instrument had about 35 percent lower dementia risk than those who rarely or never played, although instrument playing alone was not clearly associated with CIND or with changes in cognitive test performance.”

“In the past, humans' primary exposure to blue light was from the sun, but in modern times, electronic devices – TVs, computer screens, and cell phones – expose us to increasing amounts of blue light, often during times of the day or night that are out of sync with our bodies' natural rhythms.”

“To keep magnesium levels up, especially if you're active and losing a lot of magnesium through sweating, adding more magnesium-rich foods to your meals or opting for supplements like magnesium glycinate or citrate can make a big difference in maintaining your cell health and overall well-being.”

“The microbiome of participants with Alzheimer's disease differed from those without Alzheimer's disease at the phylum, order, and family levels (i.e., scientific categories used to organize microbes into groups using their genes), with higher levels of phyla Bacteroidetes and lower levels of the phyla Actinobacteria and Verrucomicrobia and family Ruminococcaceae.”

“Brain networks involved in higher-level functions such as self-related thought, flexible thinking, and staying focused on goals became more strongly linked with networks that process vision and body movement. This was the most consistent shared effect across the full dataset.”

“Good dietary sources of methyl donors include egg yolks and soy foods (high in choline); whole grains (high in betaine); green vegetables (high in folate); and meat, dairy, and fortified products (high in vitamin B12).”

“At about age 10, the children took a series of cognitive tests that included measures of memory, attention, processing speed (how quickly they handled simple mental tasks), working memory (holding and using information briefly), executive function (skills such as planning and switching between tasks), and estimated intelligence.”

“- Arthur Brooks, Ph.D. The episode closes with a framework from Brooks's work on the second half of life: jump, serve, worship, and connect, a framework he outlines in one of his earlier books, From Strength to Strength: "Jump" means proactively building the next thing, especially during liminal periods or unwelcome change, which Brooks sees as fertile ground for creativity.”

“- Brad Schoenfeld, Ph.D. Highlighting a certain hypocrisy, Dr. Schoenfeld points out that while most parents won't blanch at their children participating in sports that are characterized by real risks of injury, they will often worry themselves unnecessarily about resistance training, which has fewer risks.”