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“Examples of tissue-specific NAD disturbances he mentions include: Alcoholism disturbs NAD in the liver. People with noise-induced hearing loss likely have NAD damage in the cochlea. In heart failure, the NAD system "comes under attack.".”

“Increased intestinal permeability (also known as "leaky gut") – a condition in which gaps form between the tight junctions that join enterocytes – allows pathogens to leak through the intestinal barrier and pass directly into the bloodstream, promoting inflammation through a specialized mechanism involving detection by toll-like receptors.”

Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“While it won't eliminate genetic susceptibility, studies suggest that it can delay onset and reduce overall risk, even in those predisposed to cancer—engaging in 1–4 and more than 7 hours per week of leisure-time physical activity reduces the risk of breast cancer by 9% and 15%, respectively, in women with a family history of breast cancer.”

“In a two-year trial of 237 postmenopausal women, approximately 9 to 10 grams per day combined with resistance training and walking did not add a bone-density benefit, so its role is better framed around muscle and physical function.”

“In 27 men with metabolic syndrome, four four-minute intervals near 90 percent of peak heart rate improved VO2 max more than work-matched moderate exercise. A two-year randomized trial used a broader progressive program in healthy, sedentary adults around age 53.”

“The heart becomes smaller and less compliant with sedentary aging, which can limit how effectively it fills during exercise. In this clip from Dr. Rhonda Patrick's appearance on PBD Podcast, she describes a two-year randomized trial in healthy but sedentary adults ages 45 to 64.”

Omega-3 fatty acids play critical roles in human health and may be beneficial in ameliorating symptoms associated with chronic health conditions and in combating aging-related diseases.

“A perplexing aspect of SARS-CoV-2, the novel coronavirus that causes COVID-19, is that people respond to it in disparate ways — some exhibiting no symptoms at all, and others experiencing life-threatening complications.”