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“A small sleep-deprivation study also found that a single, higher weight-based creatine dose improved selected cognitive tasks during one night without sleep, an early result that invites further study. Product quality and individual context help determine whether a supplement is appropriate.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“Sugar substitutes are food products or additives that provide the sweet taste of sugar, without the calories. Evidence suggests that sugar substitutes have surprising effects on human metabolism and these effects vary person-to-person, based on the overall makeup of an individual's gut microbiome.”

“Many people may find the prolonged fast too onerous, but the fasting-mimicking diet, an approach that recapitulates many of the same effects of prolonged fasting with a hyper-low calorie, low protein, higher fat diet stretched out over a longer interval of five days, may offer a more palatable strategy for activating autophagy.”

“However, for people who engage in regular physical activity, the body's demand for magnesium escalates (as much as 20 percent) due to increased loss through sweat and the stress of physical activity, which depletes magnesium.”

“In this video, Dr. Darya & Kevin Rose talk about beta-hydroxybutyrate, an endogenous ketone body that increases in concentration during times of fasting or carbohydrate restriction. Beta-hydroxybutyrate also increases during a fasting-mimicking diet, which is a time of temporary period of calorie and protein restriction that generates many of the same biochemical effects of prolonged fasting.”

Dr. Rhonda Patrick discusses joint aging prevention, avoiding heavy metals in protein, reducing migraines, nicotinamide for skin, and minimizing jet lag.

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“Dr. Longo has made huge contributions to the field of aging, including the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases.”

“Insulin Sensitivity, Lactate, and Type 2 Diabetes On the metabolic side, vigorous exercise reduces the risk of diabetes mainly by improving insulin sensitivity (along with potential improvements in body weight and body composition). This happens for two reasons.”