Taking common non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen for only a week may increase heart attack risk by as much as 50%.
“First, NSAIDs have been shown to inhibit the production of a molecule called prostacyclin that relaxes blood vessels and "unglues" platelets. Second, they have been shown to inhibit the production of nitric oxide (which cox 2 also regulates to some degree).”