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“To forestall anabolic resistance, public health experts recommend adults engage in muscle-strengthening activities such as resistance training at least twice a week, with sessions lasting about 30 to 45 minutes each.”

“In animal models, mice fed a medium-chain triglyceride supplemented ketogenic diet ran farther and faster on a treadmill than animals fed standard chow. In humans, the data supporting the benefit of ketones on performance are less clear.”

“Sprint-interval exercise improved reaction time on selected executive-function tasks for about 10 to 30 minutes in a controlled study, supporting Dr. Patrick's practice of using a short workout before an early talk or demanding meeting.”

“But implementing a ketogenic diet is challenging. In this Aliquot, Dr. Dominic D'Agostino explains how to avoid side effects on a ketogenic diet, provides valuable pointers for success, and explains how the diet might help preserve muscle mass.”

“Researchers have observed synergism between the ketogenic diet and hyperbaric oxygen against tumor cells. Moreover, Dr. D'Agostino suggests that ketosis stimulates the immune system, increasing its ability to detect cancer cells.”

“In a randomized trial of resistance-trained women, an eight-hour eating window did not reduce gains in lean mass, muscle thickness, strength, or performance when energy and protein intake were matched and the participants completed supervised resistance training.”

“But with their rise in popularity come important questions about long-term effects and safe use. In this Aliquot, I discuss how these drugs work, their pros and cons, the latest research, and lifestyle strategies to optimize their effects for long-term health.”

“And one potential strategy for mitigating our risk for Alzheimer's disease as we age is a "cognoscopy" – a battery of assessments that measures some of the key biomarkers associated with the disease and can inform the trajectory of treatment.”

“Diet stands out as low-hanging fruit for influencing our lifespan. Optimizing macronutrient intake, practicing time-restricted eating, and consuming healthful bioactive compounds are critical aspects of a healthy diet. In part II of this two-part Aliquot, Drs.”

“Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects.”