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Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

Dr. Rhonda Patrick discusses sunscreen safety, HIIT & brain health, diet, omega-3s, urolithin A, sulforaphane, homocysteine, peptides, and CoQ10.

“Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects.”

“Exogenous ketones are a method to elevate circulating ketone bodies without a calorie- or carbohydrate restricted diet or extended fasting and include medium-chain triglycerides (MCTs), BHB salts, and ketone esters.”

“Evidence continues to emerge that illustrates that the fasting-mimicking diet, particularly its ability to cause immune cell turnover, may provide beneficial effects in the treatment of auto-immune diseases such as multiple sclerosis.”

“Assessments of episodic memory based on a battery of cognitive tests demonstrated that the rate of cognitive decline experienced by healthy, older people who had amyloid-beta protein accumulation in their brain and who were APOE4 and BDNF Met carriers was roughly three times the rate of decline among those carrying only the BDNF Val allele (the more common form of the gene that retains valine).”

“Dr. Michael Snyder, a recent podcast guest, maintains that closely tracking blood sugar levels with continuous glucose monitors (CGMs), for example, can alert people when their levels reach prediabetic or diabetic ranges.”

“Robust evidence from epidemiological, clinical, rodent, and in vitro studies has demonstrated that sulforaphane exhibits antioxidant and anti-inflammatory properties and may be beneficial against a wide range of chronic and acute diseases, including autism, cancer, metabolic dysfunction, and many others and may ameliorate some of the harmful effects associated with exposure to air pollution.”

“Prolonged endurance exercise, heavy sweating, sauna use, and a minimally processed diet can also increase the practical need to replace electrolytes, which is different from routinely adding large doses for a sedentary person eating processed foods.”

“It also supplies relatively little elemental magnesium and should not be counted as a complete intake strategy. She finds the evidence for Epsom-salt baths and other transdermal magnesium inadequate because skin absorption and clinically meaningful delivery have not been established.”