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Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.

“Body temperature, metabolism, and hibernation "Sauna may mimic some exercise-like stress responses. Lower body temperature and hibernation may slow metabolism. Both are interesting, but they are different biological ideas.".”

“Few topics come up in their discussion where Dr. Fahey doesn't have an anecdote about a study he was involved in, or, in some cases, "tribal knowledge" that may not even be published but is nonetheless interesting and an important part of the story that is unique to his particular vantage point.”

“In eight young men, seven days of 1,000 milligrams of NR per day changed selected muscle NAD metabolites but did not alter substrate use, mitochondrial respiration, or signaling involved in adaptation to one hour of endurance exercise.”

“Randomized-trial meta-analysis suggests that properly formulated zinc acetate or zinc gluconate lozenges providing more than 75 milligrams of elemental zinc per day can shorten common-cold duration when started early.”

“Among large clinical studies, lutein intake between three and five milligrams per day was most effective for reducing the risk of age-related macular degeneration, a leading cause of vision loss in older adults.”

“In a separate analysis of seven intervention trials involving people with type 2 diabetes, HbA1c fell by about 0.71 percentage points, total cholesterol by 23 mg/dL, and LDL cholesterol by 22 mg/dL.”

“Caloric restriction, a potent inducer of autophagy, extends lifespan in many organisms but also reduces the risk of many age-related chronic diseases, such as diabetes, cardiovascular disease, cancer, and brain atrophy – likely attributable to the beneficial effects of autophagy.”

“Key Takeaways on Sleep Timing and Health "​​these results explain part of why one might not feel as good when they go to bed at an odd time, sleep in until noon, or eat a late-night meal—the body just isn't primed (from a chronobiological perspective) to handle this quick shift."”

“The mechanisms associated with vigorous exercise—such as lactate signaling, BDNF, blood flow, and myokine release—are biologically interesting, but evidence from full workouts should not automatically be attributed to a 20-second snack.”