One night of sleep deprivation led to a 5% increase in amyloid beta plaques in brain regions that play a role in the early stage of Alzheimer's.
“Sleep activates one of the main systems that clean out amyloid beta plaques, called the glymphatic system. Future studies need to determine whether "catch-up sleep" can help ameliorate some of the negative effects that sleep deprivation has on the amyloid build up in the brain.”