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Aliquot #106: The Science of Longevity Vitamins: Taurine, Ergothioneine, and PQQ
“A May 2025 Nature paper showed taurine uptake may fuel aggressive myeloid leukemias in laboratory and mouse models, illustrating how nutrients beneficial to healthy tissues may also feed certain cancers.”
Q&A
Q&A #50: Which Additives in Processed Foods Are Most Harmful—and Does Taurine Extend Healthspan?
Dr. Rhonda Patrick explores taurine's longevity role, cocoa flavanols, training adaptations, and oral hyaluronic acid in a Q&A.
Creatine
“Specifically, healthy collegiate athletes who supplemented daily for four weeks with 15.75 grams of creatine mixed with glucose, taurine, and an electrolyte supplement experienced a 13 percent increase in high-density lipoproteins (HDL) – proteins that deliver cholesterol back to the liver – and a 13 percent decrease in VLDL.”
Magnesium
“However, a study involving more than 2,500 mentally healthy older adults found that a higher daily dietary magnesium intake (at least 407 milligrams) was linked to better overall brain function, primarily among non-Hispanic white females with adequate vitamin D status, underscoring the interdependence of the two nutrients.”
Taurine facilitates the gut microbiota's response to infection.
“Taurine breaks down to form hydrogen sulfide, a gas that promotes cardiovascular health and may be useful in treating Alzheimer's disease. Low taurine levels promote pathogenic colonization of the human gut, but high levels help resist it.”
Taurine supplementation can help regulate blood glucose and lower blood pressure, reducing risk factors associated with metabolic syndrome.
“A recent meta-analysis found that taurine supplementation improves conditions associated with metabolic syndrome. Researchers analyzed the findings of 25 studies (with more than 1,000 participants) investigating links between taurine supplementation and metabolic syndrome.”
Taurine supplementation extends life by 12 percent in animal studies, pointing to a potentially promising anti-aging strategy that may highlight the r
“Among mice that received taurine, median lifespan increased by 10 to 12 percent, roughly equivalent to about eight years in humans. They repeated their experiment in monkeys, worms, and yeast and observed similar effects.”
Vitamin C and taurine normalize blood vessel endothelial functioning as measured by flow mediated dilation
“The smokers were given either two grams per day of vitamin C for five days or 1.5 grams per day of taurine. [...] > The researchers report that taurine restored normal vessel function according to [flow mediated dilation (FMD)] measurements.”
10 potential "longevity vitamins" including ergothioneine, PQQ, queuine, taurine, lutein, zeaxanthin, astaxanthin & more.
“These putative "longevity vitamins" include: ergothioneine (a fungal antioxidant found in mushrooms), queuine (a bacterial metabolite found in the gut), PQQ (a bacterial metabolite in soil that is taken up by plants ), lutein and zeaxanthin (concentrated in leafy greens), lycopene (found in tomatoes), alpha- and beta-carotene, and cryptoxanthin (all plant antioxidant carotenoids)…”
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