Related Episodes for Autophagy

“Activation of this important system of immunosurveillance is a predictor of the long-term efficacy of chemotherapy and may help to explain the complex relationship of autophagy with cancer, wherein the initial suppression of autophagy may help prevent attracting undue attention from the immune system, but may later facilitate ongoing transformation.”

“Modulating autophagy – through fasting and exercise (which both increase acetyl CoA) or intake of nutrients like spermidine – represents a promising therapeutic approach for extending human lifespan and healthspan.”

“It has attracted interest for its potential to activate mitophagy, the process cells use to clear out damaged mitochondria. In this Aliquot, I explain why mitochondrial cleanup matters for aging, why urolithin A production varies, and what early human studies suggest about its potential benefits.”

“Coffee consumption is associated with protection from several chronic diseases. Coffee's beneficial effects may stem from its ability to induce autophagy; however, other evidence points to the benefits of caffeine, which can reset the body's internal clocks in the morning.”

“In this clip, Dr. Ruth Patterson describes how eating following the body's circadian clock, eating during the day and fasting at night, enables the body to focus on repair rather than on the digestion of food.”

“Dr. Mattson contends that unstressed cells become complacent, making them more vulnerable to the stressors that cause disease, including oxidative stress and inflammation. In modern times, fasting and exercise are behaviors that mildly stress cells.”

“In the modern-day with no imposed fasting, these cycles of renewal may remain dormant. In this clip, Dr. Valter Longo discusses how cellular repair mechanisms may have evolved during times of fasting, but are latent in times of food abundance.”

“In the prospective Framingham Offspring Study, people in the highest red-blood-cell DHA group had approximately 49 percent lower risk of developing Alzheimer's disease than those in the lowest group.”

“In a 12-week randomized trial of 291 adults exposed to substantial air pollution, a defined broccoli-sprout beverage increased urinary excretion of glutathione-linked metabolites by 61 percent for benzene and 23 percent for acrolein.”

“In later randomized trials, urolithin A improved some laboratory measures of muscle endurance or hamstring strength, but it did not significantly improve key primary outcomes such as six-minute walk distance, muscle ATP production, or peak power.”