FoundMyFitness library
Ranked by shared topics.
Biological aging clocks use DNA methylation patterns and other biomarkers to estimate different dimensions of biological aging, including how old the body appears at the molecular level, how quickly aging-related changes are accumulating, and whether lifestyle or medical interventions may be changing the trajectory of aging.
“Researchers evaluated the effects of these changes in a study involving 37 men and women who practiced voluntary long-term caloric restriction (approximately 30 percent of habitual intake) for 3 to 15 years, compared to sedentary and fit people eating a traditional Western diet.”
“In a randomized crossover study, eight trained men completed four days of daily cycling while eating either a low-carbohydrate, high-fat diet (12 percent carbohydrate) or a normal-carbohydrate diet (62 percent carbohydrate).”
“Drinking two to three cups per day is linked to roughly a 60% reduced risk of developing diabetes, a statistic that highlights coffee's robust metabolic benefits that arise from its ability to activate AMP-activated protein kinase (AMPK), a critical regulator of cellular energy metabolism.”
“The analysis pooled data from 23 studies comprising 606 participants and determined the mean difference of neuromuscular performance (jump performance and sprint times), subjective measures of fatigue, muscle soreness, and biochemical markers, following either cold water immersion or passive recovery performed no less than 24-hours post-exercise stressor.”
“In laboratory tests, the redesigned factors produced more than 50-fold higher expression of stem-cell reprogramming markers than wild-type controls and generated stable induced pluripotent stem cell lines across multiple donors and delivery methods.”
“When we engage in high-intensity exercise, our muscles become mini biochemical laboratories, synthesizing compounds like lactate and myokines that circulate throughout the body and travel to our organs, where they exert a variety of signaling effects, including the synthesis of brain-derived neurotrophic factor (BDNF) in the brain.”
“Multiple age-related inputs can keep innate immune pathways active, including the senescence-associated secretory phenotype, mitochondrial damage and oxidative stress, debris released by injured cells, visceral adipose tissue inflammation, chronic infections, increased intestinal permeability, and dysbiosis.”
“If you focus on eating multiple protein-containing meals each day and are thoughtful about your sources, it's likely you'll meet daily protein needs and thrive, whether your goal is gaining more muscle or just staying strong into your later years.”
“Increased intestinal permeability (also known as "leaky gut") – a condition in which gaps form between the tight junctions that join enterocytes – allows pathogens to leak through the intestinal barrier and pass directly into the bloodstream, promoting inflammation through a specialized mechanism involving detection by toll-like receptors.”